Ontology highlight
ABSTRACT:
SUBMITTER: Pierini A
PROVIDER: S-EPMC5436085 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Nature communications 20170509
Foxp3<sup>+</sup> regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affected HSCs or bone marrow cells into Treg-competent recipients. B-cell reconstitution is abrogated in both syngen ...[more]