Ontology highlight
ABSTRACT:
SUBMITTER: Moon AM
PROVIDER: S-EPMC54814 | biostudies-other | 1990 Oct
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19901001 19
DNA sequences located in a region 6-18 kilobases (kb) upstream from the human epsilon-globin gene are known as the locus-activating region (LAR) or dominant control region. This region is thought to play a key role in chromatin organization of the beta-like globin gene cluster during erythroid development. The beta-globin LAR activates linked globin genes in transiently or stably transfected erythroleukemia cells and in erythroid cells of transgenic mice. Since the human beta-globin LAR is funct ...[more]