Long non-coding RNAs in cutaneous melanoma: clinical perspectives.

ABSTRACT: Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the pathogenesis of cutaneous melanoma through a variety of pathways and molecular interactions. Some of these lncRNAs are possible biomarkers or therapeutic targets for malignant melanoma.

SUBMITTER: Hulstaert E 

PROVIDER: S-EPMC5522162 | biostudies-other | 2017 Jun

REPOSITORIES: biostudies-other