Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira-Gonzalez S
PROVIDER: S-EPMC5844882 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Nature communications 20180309 1
Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under pathological circumstances, senescence can adversely affect organ function, viability and regeneration. We have developed a mouse model of biliary senescence, based on the conditional deletion of Mdm2 in bile ducts under the control of the Krt19 promoter, that exhibits features of biliary disease. Here we report that senescent cholangiocytes induce ...[more]