Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC5978808 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Oncogene 20180314 22
Copy number alterations (CNAs) are crucial for colorectal cancer (CRC) development. In this study, DEAD box polypeptide 27 (DDX27) was identified to be highly amplified in both TCGA CRC (474/615) and primary CRC (47/103), which was positively correlated with its mRNA overexpression. High DDX27 mRNA (N = 199) and protein expression (N = 260) predicted poor survival in CRC patients. Ectopic expression of DDX27 increased CRC cells proliferation, migration and invasion, but suppressed apoptosis. Con ...[more]