Ontology highlight
ABSTRACT:
SUBMITTER: Du P
PROVIDER: S-EPMC5990487 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Cell stem cell 20180524 6
The embryonic stem cell (ESC) transition from naive to primed pluripotency is marked by major changes in cellular properties and developmental potential. ISY1 regulates microRNA (miRNA) biogenesis, yet its role and relevance to ESC biology remain unknown. Here, we find that highly dynamic ISY1 expression during the naive-to-primed ESC transition defines a specific phase of "poised" pluripotency characterized by distinct miRNA and mRNA transcriptomes and widespread poised cell contribution to mou ...[more]