Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients with allograft rejection.

ABSTRACT: The regulatory function of CCR7+CD8+ T cells against effector T-cells involved in T-cell mediated rejection (TCMR) in kidney transplant recipients was investigated. In vitro experiments explored the ability of CCR7+CD8+ T cells to suppress T-cell proliferation under T-cell activation conditions or during coculture with human renal proximal tubular epithelial cells (HRPTEpiC). In an ex vivo experiment, the proportion of CCR7+/CD8+, FOXP3+/CCR7+CD8+ T and effector T-cell subsets were compared between the normal biopsy control (NC, n?=?17) and TCMR group (n?=?17). The CCR7+CD8+ T cells significantly suppressed the proliferation of CD4+ T cells and significantly decreased the proportion of IFN-?+ and IL-17+/CD4+ T cells and inflammatory cytokine levels (all p?

SUBMITTER: Kim KW 

PROVIDER: S-EPMC5995850 | biostudies-other | 2018 Jun

REPOSITORIES: biostudies-other