Ontology highlight
ABSTRACT:
SUBMITTER: Wroblewski M
PROVIDER: S-EPMC6058788 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Haematologica 20180322 6
Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1 treatment decreases the numbers of pre-, immature and mature B cells while numbers of early pro-B cells remain constant. In addition, JQ1 treatment increases apoptosis in T cells, all together leading ...[more]