Ontology highlight
ABSTRACT:
SUBMITTER: Liu YF
PROVIDER: S-EPMC6117479 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Stem cell reports 20180621 1
The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, the molecular events in the HSC niche remain to be investigated. Here, we report that intercellular adhesion molecule-1 (ICAM-1) maintains HSC quiescence and repopulation capacity in the niche. ICAM-1-deficient mice (ICAM-1<sup>-/-</sup>) displayed significant expansion of phenotypic long-term HSCs with impaired quiescence, as well as fav ...[more]