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Biological role of miR-204 and miR-211 in melanoma.

ABSTRACT: In this short report, we pinpoint some technical and conceptual flaws that we found in the article entitled "miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma" (Díaz-Martínez et al., Cancer Research 2018). We also discuss how, in our opinion, these flaws led Díaz-Martínez and colleagues to incorrect conclusions about the biological role that miR-204 and miR-211 play in melanoma and about the terms of their involvement in the phenomenon of resistance to BRAF inhibitors.

SUBMITTER: Vitiello M

PROVIDER: S-EPMC6142896 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

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Biological role of miR-204 and miR-211 in melanoma.

Vitiello Marianna M D'Aurizio Romina R Poliseno Laura L

Oncoscience 20180701 7-8

In this short report, we pinpoint some technical and conceptual flaws that we found in the article entitled "miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma" (Díaz-Martínez et al., Cancer Research 2018). We also discuss how, in our opinion, these flaws led Díaz-Martínez and colleagues to incorrect conclusions about the biological role that miR-204 and miR-211 play in melanoma and about the terms of their involvement in the phenomenon of resistance to BRAF inhibitors ...[more]

PMID: 30234146

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