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Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications.

ABSTRACT: Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe?O?·DA-BSA/HA in water. Fe?O?·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe?O?·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.

SUBMITTER: Vismara E 

PROVIDER: S-EPMC6152103 | biostudies-other | 2017 Jun

REPOSITORIES: biostudies-other

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Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications.

Vismara Elena E   Bongio Chiara C   Coletti Alessia A   Edelman Ravit R   Serafini Andrea A   Mauri Michele M   Simonutti Roberto R   Bertini Sabrina S   Urso Elena E   Assaraf Yehuda G YG   Livney Yoav D YD  

Molecules (Basel, Switzerland) 20170622 7

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe₃O₄·DA-BSA/HA in water. Fe₃O₄·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the par  ...[more]

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