Ontology highlight
ABSTRACT:
SUBMITTER: Kotsiou OS
PROVIDER: S-EPMC6207585 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Frontiers in immunology 20181024
Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by promoting wound healing and tissue repair. However, it is also involved in the loss of balance between extensive inflammation and tissue regeneration lead to remodeling, the hallmark of fibrosis. The aim of the current review is to critically evaluate the available evidence regardi ...[more]