Ontology highlight
ABSTRACT:
SUBMITTER: Lee B
PROVIDER: S-EPMC6478872 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Nature communications 20190423 1
Animals often develop in environments where conditions such as food, oxygen and temperature fluctuate. The ability to adapt their metabolism to these fluctuations is important for normal development and viability. In most animals, low oxygen (hypoxia) is deleterious. However some animals can alter their physiology to tolerate hypoxia. Here we show that TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila. We find that hypoxia rapidly suppresses TORC1 ...[more]