Ontology highlight
ABSTRACT:
SUBMITTER: Jones GG
PROVIDER: S-EPMC6557854 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Nature communications 20190610 1
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases. Here we show that genetic inhibition of SHOC2 suppresses tumorigenic growth in a subset of KRAS-mutant NSCLC cell lines and prominently inhibits tumour development in autochthonous murine ...[more]