Unknown

Dataset Information

0

High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features


ABSTRACT: Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while their low variability paralogs (non-hvNLRs) are conserved between ecotypes. At a population level, hvNLRs provide new pathogen recognition specificities, but the association between allelic diversity and genomic and epigenomic features has not been established. Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and closer proximity to transposable elements than non-hvNLRs. hvNLRs show elevated synonymous and nonsynonymous nucleotide diversity and are in chromatin states associated with an increased probability of mutation. Diversifying selection maintains variability at a subset of codons of hvNLRs, while purifying selection maintains conservation at non-hvNLRs. How these features are established and maintained, and whether they contribute to the observed diversity of hvNLRs is key to understanding the evolution of plant innate immune receptors.

SUBMITTER: Ms. Chandler, Anne Sutherland 

PROVIDER: S-SCDT-10_1038-S44319-024-00122-9 | biostudies-other |

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC9882162 | biostudies-literature
| S-EPMC2630076 | biostudies-literature
| S-EPMC3157454 | biostudies-literature
| S-EPMC5559309 | biostudies-literature
| S-EPMC8505325 | biostudies-literature
| S-EPMC2908698 | biostudies-literature
| S-EPMC8660599 | biostudies-literature
| S-EPMC1449776 | biostudies-literature
| S-EPMC2734157 | biostudies-other
| S-EPMC3116908 | biostudies-literature