Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies

ABSTRACT: Viral neuroinfections represent a major health burden for which the development of antivirals is needed. Antiviral compounds that target the consequences of a brain infection (symptomatic treatment) rather than the cause (direct-acting antivirals) constitute a promising mitigation strategy that requires to be investigated in relevant models. However, physiological surrogates mimicking an adult human cortex are lacking, limiting our understanding of the mechanisms associated with viro-induced neurological disorders. Here, we optimized the Organotypic culture of Post-mortem Adult human cortical Brain explants (OPAB) as a preclinical platform for Artificial Intelligence (AI)-driven antiviral studies. OPAB shows robust viability over weeks, well-preserved 3D cytoarchitecture, viral permissiven

SUBMITTER: Emma Partiot 

PROVIDER: S-SCDT-10_1038-S44321-024-00039-9 | biostudies-other |

REPOSITORIES: biostudies-other