Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells

ABSTRACT: Somatic cells acclimate to changes in the environment by temporary reprogramming. Much has been learned about transcription factors that induce these cell-state switches in both plants and animals, but how cells rapidly modulate their proteome remains elusive. Here, we show rapid induction of autophagy during temporary reprogramming in plants triggered by phytohormones, immune and danger signals. Quantitative proteomics following sequential reprogramming revealed that autophagy is required for timely decay of previous cellular states and for tweaking the proteome to acclimate to the new conditions. Signatures of previous cellular programs thus persist in autophagy deficient cells, affecting cellular decision-making. Concordantly, autophagy deficient cells fail to acclimatize to dynamic cli

SUBMITTER: Dr. Eleazar Rodriguez 

PROVIDER: S-SCDT-EMBOJ-2019-103315 | biostudies-other |

REPOSITORIES: biostudies-other