Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis

ABSTRACT: Host-virus protein-protein interactions play key roles in the lifecycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a comprehensive interactome study between the virus and host cells using tandem affinity purification and proximity labeling strategies and identified 437 human proteins as the high-confidence interacting proteins. Further characterization of these interactions and comparison to other large-scale study of cellular responses to SARS-CoV-2 infection elucidated how distinct SARS-CoV-2 viral proteins participate in its lifecycle. With these data mining, we discovered potential drug targets for the treatment of COVID-19. The interactomes of two key SARS-CoV-2-encoded viral proteins, NSP1 and N, were compared with the interactomes of their counterp

SUBMITTER: Zhen Chen 

PROVIDER: S-SCDT-EMBOJ-2021-107776 | biostudies-other |

REPOSITORIES: biostudies-other