The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication

ABSTRACT: While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves inter-organ communication with metabolic organs, such as the liver, through BAT-derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein (PLTP). We found that increased circulating levels of PLTP, via systemic or BAT-specific overexpression, significantly improves glucose toleranc

SUBMITTER: Dr. Shingo Kajimura 

PROVIDER: S-SCDT-EMBOR-2019-49828-T | biostudies-other |

REPOSITORIES: biostudies-other