Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

ABSTRACT: Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious insulin sensitization. However, a better understanding of the context-specific PPARg responses is required for the development of novel approaches with reduced side effects. Here we identified the transcriptional cofactor Cited4 as a target and mediator of rosiglitazone in human and murine adipocyte progenitor cells, where it promoted specific sets of the rosiglitazone-dependent transcriptional program. In mice, Cited4 was required for the proper induction of thermogenic expression by Rosi speci

SUBMITTER: Dr. Irem Bayindir-Buchhalter 

PROVIDER: S-SCDT-EMM-2017-08613 | biostudies-other |

REPOSITORIES: biostudies-other