D-Aspartate treatment attenuates myelin damage and stimulates myelin repair

ABSTRACT: Glutamate signaling may orchestrate oligodendrocyte precursor cell (OPC)development and myelin regeneration through the activation of glutamate receptors at OPC-neuron-synapses.D-Aspartate is a D-aminoacid exerting modulatory actions at glutamatergic synapses. Chronic administration of D-Aspartate has been proposed as therapeutic treatment in diseases related to myelin dysfunction and NMDA receptors hypofunction, including schizophrenia and cognitive deficits.Here we show, by using an in vivo remyelination model, that administration of D-Aspartate during remyelination improved motor coordination, accelerated myelin recovery and significantly increased the number of small-diameter myelinated axons.Chronically administered during demyelination, D-Aspartate also attenuated myelin loss and inf

SUBMITTER: Dr. Francesca Boscia 

PROVIDER: S-SCDT-EMM-2018-09278 | biostudies-other |

REPOSITORIES: biostudies-other