Ontology highlight
ABSTRACT:
SUBMITTER: Tomas Helikar
PROVIDER: 1778 | Cell Collective |
REPOSITORIES: Cell Collective
Rodríguez Alfredo A Sosa David D Torres Leda L Molina Bertha B Frías Sara S Mendoza Luis L
Bioinformatics (Oxford, England) 20120120 6
<h4>Motivation</h4>Fanconi anemia (FA) is a chromosomal instability syndrome originated by inherited mutations that impair the Fanconi Anemia/Breast Cancer (FA/BRCA) pathway, which is committed to the repair of DNA interstrand cross-links (ICLs). The disease displays increased spontaneous chromosomal aberrations and hypersensitivity to agents that create DNA interstrand cross-links. In spite of DNA damage, FA/BRCA-deficient cells are able to progress throughout the cell cycle, probably due to th ...[more]