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Genomics of Brain Metastases

ABSTRACT:

Brain metastases are the most frequently occurring intracranial tumors in adults. Median survival after the diagnosis of a brain metastasis is in the order of a few months. Despite its large burden of disease and devastating clinical sequelae, we continue to have a limited understanding of the molecular mechanisms driving brain metastasis. We subjected 86 trios consisting of primary tumor, brain metastasis, and matched normal tissue to whole exome sequencing (WES). To analyze the data, we developed novel computational tools to perform an integrative analysis of somatic single nucleotide variants (SSNVs) and somatic copy-number alterations (SCNAs). This analysis allowed us to estimate the clonal architecture of the primary and metastatic samples of each patient, and to reconstruct a phylogenetic tree relating all of the subclones.

PROVIDER: phs000730 | dbGaP |

SECONDARY ACCESSION(S): PRJNA242369PRJNA242368

REPOSITORIES: dbGaP

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GapExchange_phs000730.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000730.BrainMetastasis.v1.p1.MULTI.pdf	Pdf
	manifest_phs000730.BrainMetastasis.v1.p1.c1.GRU.pdf	Pdf
	manifest_phs000730.BrainMetastasis.v1.p1.c2.DS-CRM.pdf	Pdf

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