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Genetic and Environmental Risk Assessment for Colorectal Cancer in Healthy Participants

ABSTRACT: RATIONALE: Evaluating the knowledge and attitudes of healthy participants toward a new diet and gene test for colorectal cancer risk may help doctors improve acceptance of colorectal cancer screening. PURPOSE: This clinical trial is studying the knowledge and attitudes of healthy participants toward genetic and environmental risk assessment for colorectal cancer.

DISEASE(S): Colon Cancer,Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2011105 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Genetic Epidemiology Risk Assessment Program or Usual Care in Colorectal Cancer Screening for Healthy Participants

Project description:RATIONALE: The Genetic Epidemiology and Risk Assessment program may be more effective than usual care in increasing the number of healthy participants who regularly receive screening for colorectal cancer. PURPOSE: This randomized clinical trial is studying the Genetic Epidemiology and Risk Assessment program to see how well it works compared with usual care to increase colorectal cancer screening in healthy participants.

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The Detection of Heat Stress by Assessing individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants

Project description:Heat stress can reduce work performance and increases the risk for work related injuries. An in-depth understanding of the molecular heat strain signature in sweat for an extended personalized molecular monitoring is lacking. The HEATSTAR project is, to the best of our knowledge, the first project to use a personalized study setting to assess the molecular signature of proteomics and metabolomics in sweat during moderate heat stress. It was investigated if biomarker candidates can be identified that allow us to differentiate between various heat stressors. For this, we conducted a personalized, cross-sectional, crossover pilot trial with randomized study visits. Healthy non-athlete participants aged 18-40 were included and four different types of heat stressors applied. The local sweat rate through technical absorbents, the whole body sweat rate, and sweat’s metabolomic as well as proteomic molecular composition were assessed.

2025-04-03 | PXD053287 | Pride

Longitudinal gene expression profiling of self-collected blood samples in COVID-19+ and healthy participants

Project description:Longitudinal cohort: 773 host response genes were profiled in previously vaccinated (n=16) and unvaccinated (n=14) COVID-19+ participants along with 5 healthy uninfected controls across a 2-week observational window Single timepoint cohort: 773 host response genes were profiled in 6 healthy uninfected participants

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The cardiovascular risk of healthy individuals studied by NMR metabonomics of plasma samples

Project description:The identification and the present wide acceptance of cardiovascular risk factors such as age, sex, hypertension, hyperlipidemia, smoking, obesity, diabetes, and physical inactivity have led to dramatic reductions in cardiovascular morbidity and mortality. However, novel risk predictors present opportunities to identify more patients at risk and to more accurately define the biochemical signature of that risk. In this paper, we present a comprehensive metabonomic analysis of 864 plasma samples from healthy volunteers, through Nuclear Magnetic Resonance (NMR) and multivariate statistical analysis (regression and classification). We have found that subjects that are classified as at high or at low risk using the common clinical markers can also be discriminated using NMR metabonomics. This discrimination is not only due to common markers (such as total cholesterol, triglycerides, LDL, HDL), but also to (p < 0.05 after Bonferroni correction) other metabolites (e.g., 3-hydroxybutyrate, α-ketoglutarate, threonine, dimethylglycine) previously not associated with cardiovascular diseases.

2015-03-03 | MTBLS46 | MetaboLights

Pathogenesis, Clinical and Biological Predictors of Growth in Environmental enteric dysfunction (EED): An Infant Birth Inception Cohort

Project description:Environmental enteric dysfunction (EED) is a major impediment to the Sustainable Development Goals of improved childhood survival and healthy growth worldwide. Few studies have directly examined the affected intestine, limiting the development of effective interventions. The Study of Environmental Enteropathy and Malnutrition (SEEM, Pakistan) followed 416 at-risk children prospectively from birth to 24 months of age in a rural district of Pakistan with a high prevalence of undernutrition. The duodenal genome-wide methylome and transcriptome was determined in 52 undernourished SEEM participants refractory to nutritional interventions and 42 North American healthy controls and celiac disease patients. Biomarkers were measured at 9 months and tested for association with growth at 24 months in training (n=166) and validation (n=84) groups within SEEM.

2021-05-19 | GSE157914 | GEO

Human herpesvirus 6B (HHV-6B) detection and genome-wide host expression profiles implicate HHV-6B as a pulmonary pathogen after hematopoietic cell transplantation

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2023-12-18 | GSE244210 | GEO

Expression data from healthy subjects and patients with M. africanum or M. tuberculosis infection

Project description:A blood transcriptome analysis was performed on a set of healthy subjects and patients infected with M. africanum (MAF) or M. tuberculosis (MTB). All study participants were recruited from Mali.

2020-04-03 | GSE147964 | GEO

Gene expression profile of epidermis from psoriasis lesions and healthy controls

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2021-02-09 | GSE166388 | GEO

Blood RNA sequencing in HIV-negative healthy volunteers and people living with HIV on effective, long-term anti-retroviral therapy

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2021-02-26 | E-MTAB-8891 | biostudies-arrayexpress

DNA Methylation Profiling Reveals Novel Pathway Implicated in Cardiovascular Diseases of Diabetes

Project description:Epigenetics was reported to mediate the effects of environmental risk factors on disease pathogenesis. To unleash the role of DNA methylation modification in the pathological process of cardiovascular diseases in diabetes, we screened differentially methylated genes by methylated DNA immunoprecipitation chip (MeDIP-chip) among the enrolled participants.

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