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TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors

ABSTRACT: This phase Ib trial studies the best way of TLR8 Agonist VTX-2337 and cyclophosphamide in treating patients with a solid tumor that has spread from the primary site (place where it started) to other places in the body (metastatic), progressed for a long time (persistent), come back (recurrent), or is growing, spreading, or getting worse (progressed). TLR8 Agonist VTX-2337 may stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving TLR8 Agonist VTX-2337 together with cyclophosphamide may be a better treatment for solid tumors.

DISEASE(S): Adenocarcinoma,Stage Iva Pancreatic Cancer,Colorectal Adenocarcinoma,Carcinoma,Stage Iv Breast Cancer,Stage Iv Skin Melanoma,Breast Neoplasms,Recurrent Melanoma Of The Skin,Metastatic Pancreatic Adenocarcinoma,Solid Neoplasm,Stage Iva Colorectal Cancer,Recurrent Pancreatic Carcinoma,Recurrent Breast Carcinoma,Carcinoma, Renal Cell,Colorectal Neoplasms,Carcinoma, Non-small-cell Lung,Pancreatic Neoplasms,Recurrent Renal Cell Carcinoma,Recurrent Colorectal Carcinoma,Melanoma,Recurrent Non-small Cell Lung Carcinoma,Stage Iv Non-small Cell Lung Cancer,Stage Ivb Colorectal Cancer,Stage Ivb Pancreatic Cancer,Stage Iv Renal Cell Cancer

PROVIDER: 2205833 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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