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Does local application of nitrates, during insertion of staplers via anal canal for bowel anastomosis prevent injury to muscles of anal canal ?

ABSTRACT: Intervention1: 0.2% Glyceryl Trinitrate: 1mg 0.2% glyceryl trinitrate, which corresponds to 2cm on the standardized measuring scale Control Intervention1: Nil: Nil Primary outcome(s): To compare anal sphincter pressure between intervention and observation groupsTimepoint: 1-3 days preoperative and 14-30 days postoperative Study Design: Randomized, Parallel Group Trial Method of generating randomization sequence:Computer generated randomization Method of allocation concealment:Sequentially numbered, sealed, opaque envelopes Blinding and masking:Participant and Outcome Assessor Blinded

DISEASE(S): Malignant Neoplasm Of Rectum,All Patients Planned For Colorectal Anastomosis Using Transanal Stapler

PROVIDER: 2579582 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Anal Canal Cancer : subclassification

Project description:Etiologically linked to HPV infection, malignancies of the anal canal have substantially increased in incidence over the last 20 years. Although most anal squamous cell carcinomas (SCC) respond well to chemoradiotherapy, for undetermined reasons, a subgroup of patients experience a poor outcome. Despite cumulative efforts for discovering independent predictors for overall survival, both nodal status and tumor size are still the only reliable factors predicting patient outcome. In the present study, we correlated both proteomic signatures and clinicopathological features of neoplastic lesions arising from two distinct portions of the anal canal: the lower part (squamous zone) and the more proximal anal transitional zone. Although microdissected cancer cells appeared indistinguishable by morphology (squamous phenotype), unsupervised clustering analysis of the whole proteome significantly highlighted the heterogeneity that exists within anal canal tumors. More importantly, two region-specific subtypes of SCC were revealed. The expression profile (sensitivity/specificity) of several selected biomarkers (keratin filaments) further confirmed the subclassification of anal (pre)cancers based on their cellular origin. Less commonly detected compared to their counterparts located in the squamous mucosa, SCC originating in the transitional zone displayed more frequently a poor or basaloid differentiation and were significantly correlated with reduced disease-free and overall survivals. Taken together, we present for the first time direct evidence that anal canal SCC comprises two distinct entities with different cells of origin, proteomic signatures and survival rates. This study forms the basis for a novel dualistic classification of anal carcinoma with implications for management, outcome expectations and possibly therapeutic approaches.

2016-12-20 | PXD004859 | Pride