Browse
Submit Data
Databases
API
Help

Dataset Information

3 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A prospective observational study evaluating intestinal microbiome as a biomarker to predict the efficacy and toxicity of BRCA1/2 mutant metastatic castration resistant prostate cancer patietns receiveing PARP inhibitors

ABSTRACT: Interventions: case series:Nil Primary outcome(s): ORR;OS;PFS;AE Study Design: Sequential

DISEASE(S): Prostate Cancer

PROVIDER: 2695487 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

A prospective observational study evaluating intestinal microbiome as a biomarker to predict the efficacy and toxicity of prostate cancer patients receiveing PARP inhibitors alone or combined with novel ADT agents

Project description:Interventions: case series:None Primary outcome(s): side effects Study Design: Sequential

| 2707329 | ecrin-mdr-crc

CYP17A1 inhibitors in castration-resistant prostate cancer.

Project description: Not available

| S-EPMC4323677 | biostudies-literature

ARHGEF38 as a novel biomarker to predict aggressive prostate cancer.

Project description: Not available

| S-EPMC7083745 | biostudies-literature

Protein profiles Insecticide resistant Ae. aegypti

Project description:Protein profiles of insecticide resistance Ae. aegypti in Penang island, Malaysia

2022-04-14 | MSV000089259 | MassIVE

Molecular mechanisms of partial resistance to Aphanomyces euteiches in Medicago truncatula (affy_molecularmechanism_medicago)

Project description:affy_molecularmechanism_medicago - affy_molecularmechanism_medicago - -Aphanomyces euteiches (Ae), a soilborne oomycete, is the causal agent of pea root rot, a major disease on various cultivated legume species. To gain insight into the mechanism underlying partial resistance to this pathogen, a pathosystem has been developed using the model legume Medicago truncatula (Mt). Two Mt accessions A17 and F83005.5 have been shown to display differential responses upon infection with Ae (partially resistance and susceptibility, respectively). Genetic analyses using a RIL population derived from a cross between those two lines lead to the identification of, prAe1, a major QTL involved in the observed partial resistance. Near isogenic lines (NIL) 5B2 and 5D2 whose genomes are identical except at the prAe1 locus (resistant alleles for 5B2, susceptible alleles for 5D2) have been generated, and the same differential response toward Ae has been found. The aim of this experiment is to analyse and compare 5B2 and 5D2 transcriptomes at 1 and 6 days after Ae inoculation to identify gene networks that are regulated in a prAe1 dependent manner.--Fifteen-day-old 5B2 or 5D2 plants were grown in vitro on M medium. The entire roots were then inoculated (or not = 0dpi) with a A. euteiches zoospores (75000zsp/ml) and harvested one or six days after inoculation. Three independent repeats were performed. 18 arrays - Medicago; resistance vs susceptibility comparison,time course,treated vs untreated comparison

2014-02-28 | E-GEOD-31198 | biostudies-arrayexpress

Molecular mechanisms of partial resistance to Aphanomyces euteiches in Medicago truncatula (affy_molecularmechanism_medicago)

Project description:affy_molecularmechanism_medicago - affy_molecularmechanism_medicago - -Aphanomyces euteiches (Ae), a soilborne oomycete, is the causal agent of pea root rot, a major disease on various cultivated legume species. To gain insight into the mechanism underlying partial resistance to this pathogen, a pathosystem has been developed using the model legume Medicago truncatula (Mt). Two Mt accessions A17 and F83005.5 have been shown to display differential responses upon infection with Ae (partially resistance and susceptibility, respectively). Genetic analyses using a RIL population derived from a cross between those two lines lead to the identification of, prAe1, a major QTL involved in the observed partial resistance. Near isogenic lines (NIL) NR2 and NS2 whose genomes are identical except at the prAe1 locus (resistant alleles for NR2, susceptible alleles for NS2) have been generated, and the same differential response toward Ae has been found. The aim of this experiment is to analyse and compare NR2 and NS2 transcriptomes at 1 and 6 days after Ae inoculation to identify gene networks that are regulated in a prAe1 dependent manner.--Fifteen-day-old NR2 or NS2 plants were grown in vitro on M medium. The entire roots were then inoculated (or not = 0dpi) with a A. euteiches zoospores (75000zsp/ml) and harvested one or six days after inoculation. Three independent repeats were performed.

2014-02-28 | GSE31198 | GEO

Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors.

Project description: Not available

| S-EPMC5880088 | biostudies-literature

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.

Project description: Not available

| S-EPMC4950506 | biostudies-literature

Cell toxicity mechanism and biomarker.

Project description: Not available

| S-EPMC6206310 | biostudies-other

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer.

Project description: Not available