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Examination of long-term prognosis in colorectal T1 cancer

ABSTRACT: Primary outcome(s): Recurrence and death

DISEASE(S): Colorectal Cancer

PROVIDER: 2724956 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection.

Project description: Not available

| S-EPMC7464364 | biostudies-literature

Acute and long-term effects of mutant p53 in vivo [MEF]

Project description:The specific roles of mutant p53’s dominant-negative (DN) or gain-of-function (GOF) properties in regulating acute response and long-term tumorigenesis is unclear. Using “knock-in” mouse strains expressing varying R246S mutant levels, we show that DN effect on transactivation is universally observed after acute p53 activation whereas the effect on cellular outcome is cell-type specific. Reducing mutant p53 levels abrogated the DN effect. Mutant p53’s DN effect protected against radiation-induced death, but did not accentuate tumorigenesis. Furthermore, the R246S mutant did not promote tumorigenesis compared to p53-/- mice in various models, even in the absence of MDM2, unlike the R172H mutant. Together, these data demonstrate that mutant p53’s DN property only affects acute responses, whereas GOF is not universal, being mutation-type specific. Transcriptomes of mouse embryonic fibroblasts harvested from embyros of different p53 genotypes were profiled. A total of 6 primary clones of MEFs were used and these cells were transformed with E1A/Ras. Data was analysed by mixed model ANOVA using Partek.

2012-12-31 | E-GEOD-40416 | biostudies-arrayexpress

Cancer-associated fibroblasts in T1 colorectal cancer

Project description:Characterization of gene expression profiles of primary human patient-derived T1 colorectal cancer-associated fibroblasts (T1CAFs) and patient-matched normal fibroblasts (NFs) by bulk RNA sequencing

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Genomic approach to refine prognosis for adjuvant therapy in early stage non-small cell lung carcinoma

Project description:Abstract from paper - Potti A, et al Keywords: Outcome, recurrence, adjuvant therapy, Early stage Non-small cell Lung Cancer, Lung Metgene Predictor

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A study of long-term prognosis after colorectal cancer surgery

Project description:Primary outcome(s): 10-year survival rate

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Impact of operation duration on short-term and long-term prognosis in patients undergoing radical colorectal surgery.

Project description: Not available

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Laser-assisted pulmonary metastasectomy increases the chance of long-term survival in patients with colorectal cancer

Project description:Interventions: Group 1: In this retrospective analysis, the following patient data are analyzed to compare the laser-assisted versus non-laser-assisted lung metastasisctomy with respect to long-term survival: Age, sex, date of primary surgery, date of lung metastasectomy, localization of the metastasis, TNM staging, existence of extrapulmonal metastasis, neoadjuvant/adjuvant systemic treatments (chemotherapy, radiotherapy), date of recurrent surgery, surgical technique, surgical access, extent of resection, number of resected lung metastases, lung function data, number of dissected lymph nodes, resection margins, duration of hospitalisation, postoperative complications, date of recurrence, localization of recurrence, treatment at recurrence, date of death Primary outcome(s): overall survival Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: treatment

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Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma

Project description:Primary tumor recurrence occurs commonly after surgical resection of lung squamous cell carcinoma (SCC). The aim of this study was to identify genes involved in recurrence in lung squamous cell carcinoma patients. Array comparative genomic hybridization (aCGH) was performed on DNA extracted from tumour tissue from 62 patients with primary lung squamous cell carcinomas. aCGH data was analysed to identify genes affected by copy number alterations that may be involved in SCC recurrence. Candidate genes were then selected for technical validation based on differential copy number between recurrence and non-recurrence SCC tumour samples. Genes technically validated advanced to tests of biological replication by qPCR using an independent test set of 72 primary lung SCC tumour samples. 18q22.3 loss was identified by aCGH as significantly associated with recurrence (p=0.038). Although aCGH copy number loss associated with recurrence was found for seven genes within 18q22.3, only SOCS6 copy number loss was both technically replicated by qPCR and biologically validated in the test set. DNA copy number profiling using 44K element array comparative genomic hybridization microarrays of 62 primary lung squamous cell carcinomas.

2011-12-25 | E-GEOD-32058 | biostudies-arrayexpress

Long-term oncological outcomes after local excision of T1 rectal cancer.

Project description: Not available

| S-EPMC9807482 | biostudies-literature

Acute and long-term effects of mutant p53 in vivo [Thymus]

Project description:The specific roles of mutant p53’s dominant-negative (DN) or gain-of-function (GOF) properties in regulating acute response and long-term tumorigenesis is unclear. Using “knock-in” mouse strains expressing varying R246S mutant levels, we show that DN effect on transactivation is universally observed after acute p53 activation whereas the effect on cellular outcome is cell-type specific. Reducing mutant p53 levels abrogated the DN effect. Mutant p53’s DN effect protected against radiation-induced death, but did not accentuate tumorigenesis. Furthermore, the R246S mutant did not promote tumorigenesis compared to p53-/- mice in various models, even in the absence of MDM2, unlike the R172H mutant. Together, these data demonstrate that mutant p53’s DN property only affects acute responses, whereas GOF is not universal, being mutation-type specific. Transcriptomes of 10 normal thymi harvested from 4-5 weeks old mice of different p53 and mdm2 genotype were profiled. Data was analysed by mixed model ANOVA using Partek.

2012-12-31 | E-GEOD-40414 | biostudies-arrayexpress

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