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PanDPI-Study (pancreatic carcinoma) and CoRDPI-Study (colorectal cancer)

ABSTRACT: Interventions: Group 1: Pancreatic cancer after curative treatment, prospective cohort, Doppler sonographic detection of occult liver metastasis after curatively treated pancreatic cancer by Doppler perfusion index. Within half a year after cessation of curative therapy the Doppler perfusion index (measurements of blood flow in arteria hepatica and vena portae) is measured. In the following 2 years, patients are contacted every six months and asked about (liver) metastasis free survival and this is correlated with the DPI. Primary outcome(s): This study investigates the association of DPI measured after surgery and (liver) metastasis free survival. The prognostic and predictive values of DPI in relation to the development of hepatic metastasis will be investigated. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: Prognosis

DISEASE(S): Malignant Neoplasm Of Rectum,Secondary Malignant Neoplasm Of Liver And Intrahepatic Bile Duct,Malignant Neoplasm Of Pancreas,Malignant Neoplasm Of Colon

PROVIDER: 73003 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not well understood. Therefore, we performed microarray analyses on whole-tumour samples of 2 human PDAC subpopulations with similar clinicopathological features, but extremely distinct survival rates after potentially curative surgery, i.e., good outcome (OS and DFSM-bM-^@M-^I>M-bM-^@M-^I50M-bM-^@M-^Imonths) versus bad outcome (OSM-bM-^@M-^I<M-bM-^@M-^I19M-bM-^@M-^Imonths and DFSM-bM-^@M-^I<M-bM-^@M-^I7M-bM-^@M-^Imonths). Additionally, liver- and peritoneal metastases were analysed and compared to primary cancer tissue. The integrin and ephrin receptor families were upregulated in all PDAC samples, irrespective of outcome, supporting an important role of the interaction between pancreatic cancer cells and the surrounding desmoplastic reaction in tumorigenesis and cancer progression. Moreover, some components, such as ITGB1 and EPHA2, were upregulated in PDAC samples with a poor outcome, Additionally, overexpression of the non-canonical Wnt/M-NM-2-catenin pathway and EMT genes in PDAC samples with bad versus good outcome suggests their contribution to the invasiveness of pancreatic cancer, with M-NM-2-catenin being also highly upregulated in metastatic tissue. Thus, we conclude that components of the integrin and ephrin pathways and EMT-related genes might serve as molecular markers in pancreatic cancer as their expression seems to be related with prognosis. Microarray analysis was performed on 'Good' and 'Bad' patient samples (samples with similar pathological characteristics were chosen based on the definition of the 2 diverse survival outcome groups and the required RIN values above 7.1), on surrounding non-tumoural pancreatic control samples, liver metastasis (LM) and peritoneal metastasis (PM). Comparisons between good vs. control, bad vs. control, good vs. bad, and primary pancreatic cancer versus metastasis were performed.

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PanDPI-Study (pancreatic carcinoma) and CoRDPI-Study (colorectal cancer)

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