Dataset Information
DKFZ-HIPO Data Access Committee of Heidelberg Center for Personalized Oncology
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000452 | EGA |
REPOSITORIES: EGA
Publications
Integrative genomic and transcriptomic analysis of leiomyosarcoma.
Nature communications 20180110 1
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknown. Here we show, using whole-exome and transcriptome sequencing, that LMS tumors are characterized by substantial mutational heterogeneity, near-universal inactivation of TP53 and RB1, widespread DNA copy number alterations including chromothripsis, and frequent whole-genome duplication. Fu ...[more]
