Dataset Information


RrDLBCL Sequencing Project Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000676

ORGANISM(S): Homo sapiens  

PROVIDER: EGAC00001000676 | EGA |


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Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.

Morin Ryan D RD   Assouline Sarit S   Alcaide Miguel M   Mohajeri Arezoo A   Johnston Rebecca L RL   Chong Lauren L   Grewal Jasleen J   Yu Stephen S   Fornika Daniel D   Bushell Kevin K   Nielsen Torsten Holm TH   Petrogiannis-Haliotis Tina T   Crump Michael M   Tosikyan Axel A   Grande Bruno M BM   MacDonald David D   Rousseau Caroline C   Bayat Maryam M   Sesques Pierre P   Froment Remi R   Albuquerque Marco M   Monczak Yury Y   Oros Kathleen Klein KK   Greenwood Celia C   Riazalhosseini Yasser Y   Arseneault Madeleine M   Camlioglu Errol E   Constantin André A   Pan-Hammarstrom Qiang Q   Peng Roujun R   Mann Koren K KK   Johnson Nathalie A NA  

Clinical cancer research : an official journal of the American Association for Cancer Research 20151208 9

<h4>Purpose</h4>Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of patients, and yet little is known about its biology.<h4>Experimental design</h4>Using exome sequencing, we characterized the mutation profiles of 38 rrDLBCL biopsies obtained at the time of progression after immunochemotherapy. To identify genes that may be associated with relapse, we compared the mutation frequency in samples obtained at relapse to an unrelated cohort of 138 diagnostic DLBCLs and s  ...[more]

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