DAC for Cardiac Translatomes of 80 Human Samples (65 DCM cases 15 controls)
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD012593
PROVIDER: EGAC00001001040 | EGA |
REPOSITORIES: EGA
Publications
The Translational Landscape of the Human Heart.
van Heesch Sebastiaan S Witte Franziska F Schneider-Lunitz Valentin V Schulz Jana F JF Adami Eleonora E Faber Allison B AB Kirchner Marieluise M Maatz Henrike H Blachut Susanne S Sandmann Clara-Louisa CL Kanda Masatoshi M Worth Catherine L CL Schafer Sebastian S Calviello Lorenzo L Merriott Rhys R Patone Giannino G Hummel Oliver O Wyler Emanuel E Obermayer Benedikt B Mücke Michael B MB Lindberg Eric L EL Trnka Franziska F Memczak Sebastian S Schilling Marcel M Felkin Leanne E LE Barton Paul J R PJR Quaife Nicholas M NM Vanezis Konstantinos K Diecke Sebastian S Mukai Masaya M Mah Nancy N Oh Su-Jun SJ Kurtz Andreas A Schramm Christoph C Schwinge Dorothee D Sebode Marcial M Harakalova Magdalena M Asselbergs Folkert W FW Vink Aryan A de Weger Roel A RA Viswanathan Sivakumar S Widjaja Anissa A AA Gärtner-Rommel Anna A Milting Hendrik H Dos Remedios Cris C Knosalla Christoph C Mertins Philipp P Landthaler Markus M Vingron Martin M Linke Wolfgang A WA Seidman Jonathan G JG Seidman Christine E CE Rajewsky Nikolaus N Ohler Uwe U Cook Stuart A SA Hubner Norbert N
Cell 20190530 1
Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, s ...[more]
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