Proteomics

Dataset Information

TranslationalLandscape_HumanHeart

ABSTRACT: Here, we analyze the expression of predicted microproteins in human heart tissue and iPSC cardiomyocytes, using shot-gun proteomics and SRM. 4 identified candidates were functionally validated by interactome studies using AP-MS (affinity purification coupled to mass spectrometry). In addition, the impact of disease-causing protein-truncating variants on translation was studied in rat heart tissue by performing shot-gun proteomics.

OTHER RELATED OMICS DATASETS IN: MODEL1109130000MODEL1909260003MODEL1909260004MODEL1703310000MODEL1909260005MODEL1909260006MODEL1311110000MODEL1311110001EGAS00001003263EGAC00001001040EGAD00001004394

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human)

TISSUE(S): Heart, Cell Culture

SUBMITTER: Marieluise Kirchner  

LAB HEAD: Norbert Hubner

PROVIDER: PXD012593 | Pride | 2019-06-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20180314_2h_DW200_RTW_10_20_GHCL_heart82_86.skyd Other
20180314_2h_DW200_RTW_10_20_GHCL_heart82_86_list2.skyd Other
20180314_2h_DW200_RTW_10_20_GHCL_heart82_86_list3.skyd Other
20180314_2h_DW200_RTW_10_20_GHCL_heart82_86_list4.skyd Other
20180314_2h_DW200_RTW_10_20_GHCL_heart82_86_list5.skyd Other
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