Models,Multiomics

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Puniya2021 - CD4+ Th2 cell metabolism model

ABSTRACT: CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. T helper 2 (Th2) cells are subtype CD4+ T cells that differentiate from naive CD4+ T cells in a specific cytokine environment. The Th2 cell model consists of 5252 reactions, 3156 metabolites, and 1127 genes. CD4+ T cell models helped identify drug targets and repurposable drugs against autoimmune diseases.

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

SUBMITTER: Bhanwar Lal Puniya  

PROVIDER: MODEL1909260005 | BioModels | 2023-11-27

REPOSITORIES: BioModels

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Publications

Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion.

Moreno A A   Ross B D BD   Blüml S S  

Journal of neurochemistry 20010401 1

A non-invasive (13)C magnetic resonance spectroscopy (MRS) technique is described for the determination of the N-acetyl-L-aspartate (NAA) synthesis rate, V(NAA), in the human brain in vivo. In controls, the mean V(NAA) was 9.2 +/- 3.9 nmol/min/g. In Canavan disease, where [NAA] is increased (p < 0.001) and [aspartate] is deceased (p < 0.001), V(NAA) was significantly reduced to 3.6 +/- 0.1 nmol/min/g (p < 0.001). These rates are in close agreement with the activity of the biosynthetic enzyme mea  ...[more]

PMID: 11279290

Publication: 1/547

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