A draft map of the human proteome

ABSTRACT: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fourier transform mass spectrometry-based proteomics technology. In-depth proteomic profiling of 30 histologically normal human samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells resulted in identification of proteins encoded by greater than 17,000 genes accounting for ~84% of the total annotated protein-coding genes in humans. This large human proteome catalog (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease. The authors request that those considering use of this dataset for commercial purposes contact [e-mail].

OTHER RELATED OMICS DATASETS IN: E-PROT-1 E-PROT-3 PAe005095 PAe004968 PAe004965 PAe004962 PAe005041 PAe005027 PAe004741 PAe004746 PAe004935 PAe004880 PAe004896 PAe004876 PAe004953 PAe004999 PAe004826 PAe005001 PAe005004 PAe004974 PAe005097 PAe004744 PAe005076 PAe005042 PAe005019 PAe005031 PAe004740 PAe004727 PAe004846 PAe005035 PAe005073 PAe004904 PAe005015 PAe005038 PAe004834 PAe004737 PAe004856 PAe004957 PAe004850 PAe004925 PAe004735 PAe004950 PAe004824 PAe005055 PAe005098 PAe004729 PAe005009 PAe004833 PAe004733 PAe005057 PAe004726 PAe004831 PAe005016 PAe004724 PAe004728 PAe004736 PAe004988 PAe005029 PAe005014 PAe004730 PAe004914 PAe004966 PAe004828 PAe004747 PAe004743 PAe004973 PAe004723 PAe004825 PAe005059 PAe004963 PAe005078 PAe004738 PAe005003 PAe004901 PAe004991 PAe004827 PAe004734 PAe004731 PAe004969 MODEL1909260003 MODEL1909260004 MODEL1909260005 MODEL1909260006 PXD000561

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Akhilesh Pandey 

PROVIDER: MSV000079514 | MassIVE | Tue Feb 16 10:39:00 GMT 2016

SECONDARY ACCESSION(S): PXD000561

REPOSITORIES: MassIVE