Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MODEL1109130000MODEL1311110000MODEL1909260003MODEL1311110001MODEL1909260004MODEL1703310000MODEL1909260005MODEL1909260006
INSTRUMENT(S): Orbitrap Fusion Lumos, Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Ilian Atanassov
LAB HEAD: Nils-Göran Larsson
PROVIDER: PXD019690 | Pride | 2020-08-03
REPOSITORIES: Pride
Motori E E Atanassov I I Kochan S M V SMV Folz-Donahue K K Sakthivelu V V Giavalisco P P Toni N N Puyal J J Larsson N-G NG
Science advances 20200828 35
Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoing progressive OXPHOS deficiency caused by disrupted mitochondrial fusion dynamics. We found that mitochondrial dysfunction triggers a profound rewiring of the proteomic landscape, c ...[more]