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Eaa4975f-4514-44a7-baa4-9404c42156a2 - samples

ABSTRACT: Whole genome sequencing dataset of 54 tumor/normal samples of 25 cHCC-ICC cases.

PROVIDER: EGAD00001005181 | EGA |

REPOSITORIES: EGA

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Publications

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Xue Ruidong R Chen Lu L Zhang Chong C Fujita Masashi M Li Ruoyan R Yan Shu-Mei SM Ong Choon Kiat CK Liao Xiwen X Gao Qiang Q Sasagawa Shota S Li Yanmeng Y Wang Jincheng J Guo Hua H Huang Qi-Tao QT Zhong Qian Q Tan Jing J Qi Lisha L Gong Wenchen W Hong Zhixian Z Li Meng M Zhao Jingmin J Peng Tao T Lu Yinying Y Lim Kiat Hon Tony KHT Boot Arnoud A Ono Atushi A Chayama Kazuaki K Zhang Zemin Z Rozen Steve George SG Teh Bin Tean BT Wang Xin Wei XW Nakagawa Hidewaki H Zeng Mu-Sheng MS Bai Fan F Zhang Ning N

Cancer cell 20190523 6

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing ...[more]

PMID: 31130341

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