Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001006339 | EGA |
REPOSITORIES: EGA
Chua Robert Lorenz RL Lukassen Soeren S Trump Saskia S Hennig Bianca P BP Wendisch Daniel D Pott Fabian F Debnath Olivia O Thürmann Loreen L Kurth Florian F Völker Maria Theresa MT Kazmierski Julia J Timmermann Bernd B Twardziok Sven S Schneider Stefan S Machleidt Felix F Müller-Redetzky Holger H Maier Melanie M Krannich Alexander A Schmidt Sein S Balzer Felix F Liebig Johannes J Loske Jennifer J Suttorp Norbert N Eils Jürgen J Ishaque Naveed N Liebert Uwe Gerd UG von Kalle Christof C Hocke Andreas A Witzenrath Martin M Goffinet Christine C Drosten Christian C Laudi Sven S Lehmann Irina I Conrad Christian C Sander Leif-Erik LE Eils Roland R
Nature biotechnology 20200626 8
To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an ave ...[more]