Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Db63ef48-eccf-41e6-92fc-4dc7923f9c04 - samples

ABSTRACT: Investigation of the function of Calcoco2 by knocking it down in beta and fat cell lines.

PROVIDER: EGAD00001008654 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Similar Datasets

RNASeq of Calcoco2 in beta and fat cell lines

Project description:Investigation of the function of Calcoco2 by knocking it down in beta and fat cell lines.

| EGAS00001006127 | EGA

beta catenin in CCA cell lines and patient samples

Project description:beta catenin in CCA cell lines and patient samples

| PRJNA841664 | ENA

Regulatory role of MAFB transcription factor in cultured human β cells

Project description:To investigate the function of MAFB in the regulation of human beta cell identity and maturity, we established EndoCbH2 cell lines in which MAFB has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from bulkRNA-seq of 3 biological replicates.

2023-09-21 | GSE228992 | GEO

Mouse Cardiac Proteomics and β-hydroxybutyrylation omics Studies

Project description:β-Hydroxybutyrylation (kbhb) is a new type of post-translational modification(PTM) of lysine acylation. In recent years, kbhb modification has been shown to be involved in energy metabolism, tumor metabolism, DNA damage repair and other processes. Currently, lysine β-hydroxybutyrylation has not been studied in cardiac tissue. In this study, we performed proteomic and β-hydroxybutyrylation modification omics analysis of mouse heart tissue based on LC-MS/MS analysis. These data provide the first mammalian cardiac kbhb dataset and provide new directions for further investigation of the function of kbhb in non-histone proteins.

2023-03-14 | PXD034269 | iProX

beta catenin in CCA cell lines and patient samples

Project description:test the activation of beta catenin in APC and CTNNB1 mutated samples (CCA cell lines and patient samples) versus WT

2022-05-26 | GSE203639 | GEO

DNMT1-associated long non-coding RNA regulate global gene expression and DNA methylation in colon cancer

Project description:The investigation of the association of long non-coding RNAs (lncRNAs) with DNMT1 by RIP-seq reveals that DNMT1 interacts with DACOR1. We identified the genomic occupancy sites of DACOR1 through ChIRP-seq, which we found to significantly overlap with known differentially methylated regions (DMRs) in colon tumors. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Consistent with the observed phenotype, induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. Notably, DACOR1 induction resulted in down-regulation of Cystathionine β-synthase (CBS), which is known to lead to increased levels of S-adenosyl methionine (SAM) – the key methyl donor for DNA methylation.

2015-09-15 | GSE58989 | GEO

RNA-seq dataset for MPNST cell lines

Project description:RNA-seq dataset for MPNST cell lines

| PRJNA593502 | ENA

Mus musculus breed:C57Bl/6

Project description:ERRgamma and Pancreatic beta-cell function

| PRJNA262821 | ENA

Effects of Sorcin (SRI) overexpression on mouse pancreatic beta cells transcriptome

Project description:Pancreatic beta cells use electrical signals to couple changes in blood glucose concentration to insulin release via extracellular calcium (Ca2+) influx. Sorcin (SRI) is a Ca2+-binding protein whose overexpression in cardiomyocytes rescues the abnormal contractile function of the diabetic heart. In order to investigate the role of sorcin in regulating mouse pancreatic beta cell transcriptome, transgenic mice were generated on a C56BL/6 background permitting inducible overexpression of SRI cDNA with the TetOn-system specifically in beta cells. Animals bearing ten copies of the SRI transgene (SRI-tg10), and littermate controls, were fed a high fat diet (60% fat, HFD) and exposed to doxycycline in the drinking water (500mg/L) from 4 weeks onwards. Microarray analysis were performed using total RNA from isolated pancreatic islets of 8-week-old mice.

2015-09-09 | E-GEOD-72719 | biostudies-arrayexpress

RNA-seq of human pancreatic cell lines, L3.6pl and BxPC-3, upon knockdown of p63 for 48 hours compared to siControl

Project description:Investigation of gene expression profile changes upon down regulation of p63 in L3.6pl and BxPC-3 cell lines which are representative of the squamous molecular subtype in pancreatic cancer

2018-12-18 | E-MTAB-7033 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data