BreastCancer_Miroarrays
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010002251 | EGA |
REPOSITORIES: EGA
Similar Datasets
Project description:Genotyping array data for normal mammary gland control samples
| EGAD00010002250 | EGA
Project description:Using LC-MS/MS, we analyzed ECM-enriched samples obtained from 1) human triple-negative breast cancer samples and matched adjacent normal mammary gland tissues, and 2) disease-free omentum from patient with non-metastatic ovarian cancer and high-grade- serous-ovarian- cancer-derived omental metastasis samples. We conducted the LC-MS/MS analysis on peptides obtained after solubilizing ECM-enriched samples using different methods (crude ECM extract, urea-soluble extract, urea-insoluble extract) and submitted to basic-reversed- phase separation or not.
2017-07-11 | PXD005554 | Pride
Project description:In this study, through coupling of our ISDoT tissue decellularisation technology with quantitative mass spectrometry, we explored the changing tumour matrisome during mammary tumourigenesis in the PyMT breast cancer model compared to age-matched healthy control mammary gland
2022-03-30 | MSV000089167 | MassIVE
Project description:The purpose of this study is to obtain comprehensive gene expression profiles in breast cancer. Mammary gland cells were specifically isolated from 433 clinical tissue samples by laser capture microdissection (LCM). Total RNAs were extracted from LCM captured samples. We investigated gene expression profiles in 417 patients with breast cancer and 16 non-tumor tissues as a normal control using an Affymetrix GeneChip. Mammary gland cells were captured from clinical tissues of breast cancer patient by LCM. Gene expression profilings for 417 tumor and 16 non-tumor samples were acquired using GeneChip Human Genome U133 Plus 2.0 (Affymetrix, Santa Clara, CA). Microarray datasets were normalized and transformed to log2 values using robust multi-array average (RMA) method with R statistical software and BioConductor package.
2014-09-16 | E-GEOD-54002 | biostudies-arrayexpress
Project description:The purpose of this study is to obtain comprehensive gene expression profiles in breast cancer. Mammary gland cells were specifically isolated from 433 clinical tissue samples by laser capture microdissection (LCM). Total RNAs were extracted from LCM captured samples. We investigated gene expression profiles in 417 patients with breast cancer and 16 non-tumor tissues as a normal control using an Affymetrix GeneChip.
2014-09-16 | GSE54002 | GEO
Project description:Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland Keywords = breast cancer Keywords = rat mammary tumor Keywords = NMU Keywords = animal model. Keywords: other
2005-04-30 | GSE1872 | GEO
Project description:To characterise the metabolic landscape of metastatic breast cancer we investigated differences in metabolites between the serum of MMTV-PyMT (Mouse Mammary Tumor Virus long terminal repeat upstream of a cDNA sequence encoding the Polyoma Virus middle T antigen) mice and their wild-type counterparts (https://doi.org/10.1101/2024.07.02.601676). Here we provide matched transcriptomic data on the primary mammary tumors from MMTV-PyMT mice and the mammary gland from FVB/N mice
2025-06-12 | GSE292202 | GEO
Project description:Fibroblasts form a major component of the stroma in normal mammary gland and breast tumors. This project aimed to proteomically characterize fibroblast populations in the mouse mammary gland across different developmental stages and during oncogenesis. CD34high and CD34low mark a populations of mesenchymal progenitor cells and specialized fibroblasts, respectively.
2025-05-06 | PXD060415 | Pride
Project description:Mammary stem cells (MaSCs) play important roles in mammary gland homeostasis. A better understanding of MaSC activity enhances our knowledge of breast cancer initiation and progression, particularly in the context of triple-negative breast cancer (TNBC). Until now, the molecular mechanisms of MaSCs have remained elusive. Our current research has unveiled a significant enrichment of IGFBP3 expression in normal MaSCs, highlighting its indispensable role in maintaining MaSCs stemness and mammary gland development. Moreover, we show that IGFBP3 promotes breast cancer tumorigenesis and progression. Mechanistically, IGFBP3 regulates IGF1/2 bioavailability under the action of MMPs (such as MMP3), activating the IGF1R receptor and its downstream AKT and ERK1/2 signaling pathways. In clinical samples, high expression of either IGFBP3 or MMP3 is associated with poor prognosis in ER-negative or TNBC patients. Future studies should investigate the potential therapeutic benefit of IGFBP3 in TNBC.
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Project description:MicroRNAs are widely expressed in the normal pubertal mammary gland and orchestrate mammary gland development by regulating cell proliferation, differentiation, apoptosis, and metabolism. Although human Growth hormone(hGH) plays fundamental roles in normal mammary gland development and elevated autocrine hGH levels have been documented to contribute to breast cancer, whether hGH should influence the expression pattern and the functional roles of miRNAs in this context remain unknown.This study explores the effects of autocrine hGH on microRNA expression in MCF7 cell.
2014-12-31 | GSE58845 | GEO