Dataset Information


Patients with metastatic urothelial carcinoma

ABSTRACT: Samples from three patients with urothelial carcinoma and paired lymph node metastases and distant metastases. Patient 1: Muscle invasive tumor and lymph node metastasis. Patient 2: Muscle invasive tumor, lymph node metastasis, and distant metastasis in the small intestine. Patient 3: T1b tumor, lymph node metastasis, and distant metastasis in the lung

ORGANISM(S): Homo sapiens  

PROVIDER: EGAS00001002114 | EGA |


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Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma.

Thomsen Mathilde B H MB   Nordentoft Iver I   Lamy Philippe P   Høyer Søren S   Vang Søren S   Hedegaard Jakob J   Borre Michael M   Jensen Jørgen B JB   Ørntoft Torben F TF   Dyrskjøt Lars L  

Molecular oncology 20160817 9

Patients with metastatic bladder cancer have a median survival of only 13-14 months. Precision medicine using targeted therapy may improve survival. Here we investigated spatial and temporal tumour evolution and tumour heterogeneity in order to evaluate the potential use of targeted treatment of metastatic bladder cancer. We performed a proof-of-concept study by whole exome sequencing of multiple tumour regions (n = 22) from three patients with metastatic bladder cancer. DNA from primary and met  ...[more]

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