VRK3 depletion in Pontine Diffuse Midline Glioma (DMG)-K27 altered cells

ABSTRACT: In order to investigate possible mechanisms underlying the phenotype of cell fitness decline observed following decrease of VRK3 in pontine DMG-K27 altered cells 7, we examined differences in global gene expression. RNA-seq was performed 44h and 60h post-transduction with two distinct shRNAs targeting VRK3 to be able to evaluate the early impact of VRK3 knock-down (KD) in four independent in vitro models of DMG

PROVIDER: EGAS00001007047 | EGA |

REPOSITORIES: EGA