Ontology highlight
ABSTRACT: Neuroblastoma is a malignancy of the developing sympathetic nervous system that most commonly affects young children and is often lethal. The etiology of this embryonal cancer is not known. We have performed a whole genome scan for association of neuroblastoma with SNP genotypes and copy number variation to discover predisposition loci. We therefore initiated a genome-wide association study (GWAS) in 2007 focused on neuroblastoma patients identified through the Children's Oncology Group (COG; 238 member institutions). Control patients for this study are children cared for at the Children's Hospital of Philadelphia (CHOP) without a diagnosis of cancer. The study was designed to collect up to 5000 neuroblastoma cases and 10,000 controls and is powered to detect common susceptibility variants in Caucasian and African American patients. Whole genome genotyping is being performed on the Illumina HH550 SNP array.
PROVIDER: phs000124.v2.p1 | EGA |
REPOSITORIES: EGA
Maris John M JM Mosse Yael P YP Bradfield Jonathan P JP Hou Cuiping C Monni Stefano S Scott Richard H RH Asgharzadeh Shahab S Attiyeh Edward F EF Diskin Sharon J SJ Laudenslager Marci M Winter Cynthia C Cole Kristina A KA Glessner Joseph T JT Kim Cecilia C Frackelton Edward C EC Casalunovo Tracy T Eckert Andrew W AW Capasso Mario M Rappaport Eric F EF McConville Carmel C London Wendy B WB Seeger Robert C RC Rahman Nazneen N Devoto Marcella M Grant Struan F A SF Li Hongzhe H Hakonarson Hakon H
The New England journal of medicine 20080507 24
<h4>Background</h4>Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known.<h4>Methods</h4>We performed a genomewide association study by first genotyping blood DNA samples from 1032 patients with neuroblastoma and 2043 control subjects of European descent using the Illumina HumanHap550 BeadChip. Samples from three independent groups of patients with neuroblastoma (a total of 720 pat ...[more]