We need your help! If you've ever found our data helpful, please take our impact survey (15 min). Your replies will help keep the data flowing to the scientific community. Please Click here for Survey

Genomics

Dataset Information

0

The mutation spectrum revealed by paired genome sequences from a lung cancer patient


ABSTRACT:

Whole genome sequencing was applied to tumor and adjacent normal lung tissue in an individual non-small-cell lung cancer patient. We present an analysis of somatic changes identified throughout the tumor genome, including single-nucleotide variants, copy number variants, and large-scale chromosomal rearrangements. Over 50,000 high-confidence single-nucleotide variants were identified, revealing evidence of substantial smoking-related DNA damage as well as distinct mutational pressures within the tumor resulting in uneven distribution of somatic mutations across the genome.

OTHER RELATED OMICS DATASETS IN: E-GEOD-20578E-GEOD-20574E-GEOD-20585

ORGANISM(S): Homo sapiens  

PROVIDER: phs000299.v1.p1 | EGA |

REPOSITORIES: EGA

altmetric image

Publications


Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell lung carcinomas in smokers being the predominant form of the disease. Although previous studies have identified important common somatic mutations in lung cancers, they have primarily focused on a limited set of genes and have thus provided a constrained view of the mutational spectrum. Recent cancer sequencing efforts have used next-generation sequencing technologies to provide a genome-wide view of muta  ...[more]

Similar Datasets

2019-01-01 | S-EPMC6607931 | BioStudies
2017-01-01 | S-EPMC5732791 | BioStudies
2010-05-27 | E-GEOD-20585 | ArrayExpress
1000-01-01 | S-EPMC5334298 | BioStudies
2012-01-01 | S-EPMC3359355 | BioStudies
2013-01-01 | S-EPMC3599340 | BioStudies
2019-01-01 | S-EPMC6775870 | BioStudies
2007-01-01 | S-EPMC1855985 | BioStudies
2016-01-01 | S-EPMC4756850 | BioStudies
| phs000299 | dbGaP