Genomics

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IgA Nephropathy GWAS (IGANGWAS)

ABSTRACT:

We report a genome-wide association study of IgA nephropathy, a main cause of kidney failure. All subjects were of Chinese Han ancestry, of which 1,194 were cases and 902 controls. Genomic DNA samples extracted from whole blood were genotyped on the Illumina 610 Quad platform.

PROVIDER: phs000431.v1.p1 | EGA |

REPOSITORIES: EGA

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Publications

Genome-wide association study identifies susceptibility loci for IgA nephropathy.

Gharavi Ali G AG   Kiryluk Krzysztof K   Choi Murim M   Li Yifu Y   Hou Ping P   Xie Jingyuan J   Sanna-Cherchi Simone S   Men Clara J CJ   Julian Bruce A BA   Wyatt Robert J RJ   Novak Jan J   He John C JC   Wang Haiyan H   Lv Jicheng J   Zhu Li L   Wang Weiming W   Wang Zhaohui Z   Yasuno Kasuhito K   Gunel Murat M   Mane Shrikant S   Umlauf Sheila S   Tikhonova Irina I   Beerman Isabel I   Savoldi Silvana S   Magistroni Riccardo R   Ghiggeri Gian Marco GM   Bodria Monica M   Lugani Francesca F   Ravani Pietro P   Ponticelli Claudio C   Allegri Landino L   Boscutti Giuliano G   Frasca Giovanni G   Amore Alessandro A   Peruzzi Licia L   Coppo Rosanna R   Izzi Claudia C   Viola Battista Fabio BF   Prati Elisabetta E   Salvadori Maurizio M   Mignani Renzo R   Gesualdo Loreto L   Bertinetto Francesca F   Mesiano Paola P   Amoroso Antonio A   Scolari Francesco F   Chen Nan N   Zhang Hong H   Lifton Richard P RP  

Nature genetics 20110313 4

We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance (P v  ...[more]

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