Dataset Information
Morpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
Ontology highlight
ABSTRACT:
SUBMITTER: Lutz Brusch
PROVIDER: 759 | FAIRDOMHub | 2020-11-27
REPOSITORIES: FAIRDOMHub
Publications
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human.
Cell reports 20191201 13
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical modeling showed that both pathways in healthy liver act largely complementary to each other in the pericentral (Wnt) and the periportal zone (Hh) and communicate mainly by mutual r ...[more]
