Transcritome analysis of herbal extract WCE mediated gene signature in 22Rv1 cells

ABSTRACT: Recurrences of hormone-refractory prostate cancer highly affect the therapeutic outcome. Although anti-androgen therapy prolongs survival in prostate cancer patients, resistance rapidly develops and is often associated with increased androgen receptor expression and upregulated HER2/3-AKT signaling pathway. However, single agent therapy targeting AR, HER2/3 or AKT usually failed due to the reciprocal feedback loop. Here, we demonstrated that herbal extract of Wedelia chinensis (WCE) effectively disrupted the androgen receptor, HER2/3, and AKT signaling network and therefore enhanced therapeutic efficacy of androgen ablation in PCa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100224 | GEO | 2017/06/21

SECONDARY ACCESSION(S): PRJNA391087

REPOSITORIES: GEO