Dataset Information


Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries)

ABSTRACT: Here, we analyzed and identified the miRNA expression profile of three different intestinal tissues (i.e., duodenum, cecum, and colon) of sheep (Ovis aries) using high-throughput sequencing and bioinformatic methods. In total, 128 known miRNAs were identified, 526 novel miRNAs were predicted, and 202 differentially expressed miRNAs were found between the different tissues. Additionally, 4,422 candidate target genes were predicted, and 185 non-redundant GO annotation terms were identified using enrichment analysis. A total of 529 target genes were found to participate in 37 KEGG biological pathways, and 270 of these genes were significantly enriched in the metabolism category. Overall design: Examination of miRNA expression in 3 sheep intestinal regions.

INSTRUMENT(S): Illumina HiSeq 2000 (Ovis aries)

SUBMITTER: Chao Tianle  

PROVIDER: GSE100649 | GEO | 2018-03-07


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Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries).

Hou Lei L   Ji Zhibin Z   Wang Guizhi G   Wang Jin J   Chao Tianle T   Wang Jianmin J  

PloS one 20180228 2

Sheep are small ruminants, and their long intestines exhibit high digestive and absorptive capacity in many different rearing conditions; however, the genetic bases of this characteristic remains unclear. MicroRNAs (miRNAs) play a major role in maintaining both intestinal morphological structure as well as in regulating the physiological functions of this organ. However, no study has reported on the miRNA expression profile in the intestinal tissues of sheep. Here, we analyzed and identified the  ...[more]

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