Genomics

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VHL restoration alters cis-regulatory landscape


ABSTRACT: VHL loss is the most common genetic alteration event in ccRCC. By profiling histone modifications from VHL-deficient ccRCC primary tumors and cell lines, we identifed tumor-associated promoters and enhancers. We next investigate whether VHL restoration alters tumor associated promoters and enhancers. We compared H3K27ac ChIP-seq with and without VHL restoration in 786-O cells. Restoration of wild-type VHL significantly altered a subset of tumor enhancers but affected promoters to a less extent.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102095 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA396574

REPOSITORIES: GEO

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