Dataset Information


Gene expression assessed by genome wide hybridization bead array in intestinal epithelial cells (IECs) isolated from small intestinal biopsies of celiac disease patients with active disease and clinical controls

ABSTRACT: Analysis of role of small intestinal epithelial cells (IECs) in the immunopathology of celiac disease Overall design: Four samples of purified IECs from duodenal mucosa of CD patients with active disease, 4 samples of purified IECs of clinical controls were individually subjected to genome-wide hybridization bead array analysis for gene expression.

INSTRUMENT(S): Illumina HumanRef-8 v3.0 expression beadchip

SUBMITTER: Marie-Louise Hammarström  

PROVIDER: GSE102991 | GEO | 2017-08-24



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Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells.

Pietz Grzegorz G   De Rituparna R   Hedberg Maria M   Sjöberg Veronika V   Sandström Olof O   Hernell Olle O   Hammarström Sten S   Hammarström Marie-Louise ML  

PloS one 20170921 9

Celiac disease is a chronic inflammatory disease of the small intestine mucosa due to permanent intolerance to dietary gluten. The aim was to elucidate the role of small intestinal epithelial cells in the immunopathology of celiac disease in particular the influence of celiac disease-associated bacteria.Duodenal biopsies were collected from children with active celiac disease, treated celiac disease, and clinical controls. Intestinal epithelial cells were purified and analyzed for gene expressio  ...[more]

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